CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.20 | Alpha-Beta Barrel | |
3.20.20 | TIM Barrel | |
3.20.20.220 |
Domain Context
CATH Clusters
Superfamily | 3.20.20.220 |
Functional Family | Methylenetetrahydrofolate reductase |
Enzyme Information
1.5.1.20 |
Methylenetetrahydrofolate reductase (NAD(P)H).
based on mapping to UniProt P0AEZ1
5-methyltetrahydrofolate + NAD(P)(+) = 5,10-methylenetetrahydrofolate + NAD(P)H.
-!- Menadione can also serve as an electron acceptor. -!- Formerly EC 1.1.1.68, EC 1.1.1.171, EC 1.1.99.15 and EC 1.7.99.5.
|
UniProtKB Entries (1)
P0AEZ1 |
METF_ECOLI
Escherichia coli K-12
5,10-methylenetetrahydrofolate reductase
|
PDB Structure
PDB | 1ZP3 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Structures of NADH and CH(3)-H(4)Folate Complexes of Escherichia coli Methylenetetrahydrofolate Reductase Reveal a Spartan Strategy for a Ping-Pong Reaction
Biochemistry
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