CATH Classification

Domain Context

CATH Clusters

Superfamily 3.20.20.220
Functional Family Methylenetetrahydrofolate reductase

Enzyme Information

1.5.1.20
Methylenetetrahydrofolate reductase (NAD(P)H).
based on mapping to UniProt P0AEZ1
5-methyltetrahydrofolate + NAD(P)(+) = 5,10-methylenetetrahydrofolate + NAD(P)H.
-!- Menadione can also serve as an electron acceptor. -!- Formerly EC 1.1.1.68, EC 1.1.1.171, EC 1.1.99.15 and EC 1.7.99.5.

UniProtKB Entries (1)

P0AEZ1
METF_ECOLI
Escherichia coli K-12
5,10-methylenetetrahydrofolate reductase

PDB Structure

PDB 1ZP3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of NADH and CH(3)-H(4)Folate Complexes of Escherichia coli Methylenetetrahydrofolate Reductase Reveal a Spartan Strategy for a Ping-Pong Reaction
Pejchal, R., Sargeant, R., Ludwig, M.L.
Biochemistry