CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.10 | Arc Repressor Mutant, subunit A |
|
1.10.10.10 | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
Domain Context
CATH Clusters
| Superfamily | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
| Functional Family | Coniferyl alcohol 9-O-methyltransferase |
Enzyme Information
| 2.1.1.212 |
2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase.
based on mapping to UniProt Q29U70
S-adenosyl-L-methionine + 2,4',7-trihydroxyisoflavanone = S-adenosyl-L- homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone.
-!- Specifically methylates 2,4',7-trihydroxyisoflavanone on the 4'-position. -!- No activity with isoflavones. -!- The enzyme is involved in formononetin biosynthesis in legumes. -!- The protein from pea (Pisum sativum) also methylates (+)- 6a-hydroxymaackiain at the 3-position (cf. EC 2.1.1.270).
|
| 2.1.1.46 |
Isoflavone 4'-O-methyltransferase.
based on mapping to UniProt Q29U70
S-adenosyl-L-methionine + a 4'-hydroxyisoflavone = S-adenosyl-L- homocysteine + a 4'-methoxyisoflavone.
-!- The enzyme catalyzes the methylation of daidzein and genistein. -!- It does not methylate naringenin, apigenin, luteolin or kaempferol.
|
UniProtKB Entries (1)
| Q29U70 |
I4OMT_MEDTR
Medicago truncatula
Isoflavone 4'-O-methyltransferase
|
PDB Structure
| PDB | 1ZG3 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses.
Plant Cell
|
