CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family GMP reductase

Enzyme Information

1.1.1.205
IMP dehydrogenase.
based on mapping to UniProt P0C0H6
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH.
-!- The enzyme acts on the hydroxy group of the hydrated derivative of the substrate. -!- Formerly EC 1.2.1.14.

UniProtKB Entries (1)

P0C0H6
IMDH_STRPY
Streptococcus pyogenes
Inosine-5'-monophosphate dehydrogenase

PDB Structure

PDB 1ZFJ
External Links
Method X-RAY DIFFRACTION
Organism Streptococcus
Primary Citation
Characteristics and crystal structure of bacterial inosine-5'-monophosphate dehydrogenase.
Zhang, R., Evans, G., Rotella, F.J., Westbrook, E.M., Beno, D., Huberman, E., Joachimiak, A., Collart, F.R.
Biochemistry