CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.2350 | Pseudouridine synthase |
|
3.30.2350.10 | Pseudouridine synthase |
Domain Context
CATH Clusters
| Superfamily | Pseudouridine synthase |
| Functional Family | tRNA pseudouridine synthase B |
Enzyme Information
| 5.4.99.25 |
tRNA pseudouridine(55) synthase.
based on mapping to UniProt Q9WZW0
tRNA uridine(55) = tRNA pseudouridine(55).
-!- Pseudourine synthase TruB from Escherichia coli specifically modifies uridine(55) in tRNA molecules. -!- The bifunctional archaeal enzyme also catalyzes the pseudouridylation of uridine(54). -!- It is not known whether the enzyme from Escherichia coli can also act on position 54 in vitro, since this position is occupied in E.coli tRNAs by thymine.
|
UniProtKB Entries (1)
| Q9WZW0 |
TRUB_THEMA
Thermotoga maritima MSB8
TRNA pseudouridine synthase B
|
PDB Structure
| PDB | 1ZE2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Conformational change of pseudouridine 55
synthase upon its association with RNA substrate
Nucleic Acids Res.
|