CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family Thioredoxin reductase 2, mitochondrial

Enzyme Information

1.8.1.9
Thioredoxin-disulfide reductase.
based on mapping to UniProt Q9JLT4
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.
-!- May be identical to EC 1.8.1.10. -!- Formerly EC 1.6.4.5.

UniProtKB Entries (1)

Q9JLT4
TRXR2_MOUSE
Mus musculus
Thioredoxin reductase 2, mitochondrial

PDB Structure

PDB 1ZDL
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism.
Biterova, E.I., Turanov, A.A., Gladyshev, V.N., Barycki, J.J.
Proc.Natl.Acad.Sci.Usa