1 keywords

CATH Domain 1zczA03

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.140 Cytidine Deaminase; domain 2
Homologous Superfamily 3.40.140.20 AICAR transformylase, duplication domain

Domain Context

CATH Clusters

Superfamily 3.40.140.20
Functional Family Bifunctional purine biosynthesis protein PurH

Enzyme Information

3.5.4.10
IMP cyclohydrolase.
based on mapping to UniProt Q9X0X6
IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
2.1.2.3
Phosphoribosylaminoimidazolecarboxamide formyltransferase.
based on mapping to UniProt Q9X0X6
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.

UniProtKB Entries (1)

Q9X0X6
PUR9_THEMA
Thermotoga maritima MSB8
Bifunctional purine biosynthesis protein PurH

PDB Structure

PDB 1ZCZ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 A resolution.
Axelrod, H.L., McMullan, D., Krishna, S.S., Miller, M.D., Elsliger, M.A., Abdubek, P., Ambing, E., Astakhova, T., Carlton, D., Chiu, H.J., Clayton, T., Duan, L., Feuerhelm, J., Grzechnik, S.K., Hale, J., Han, G.W., Haugen, J., Jaroszewski, L., Jin, K.K., Klock, H.E., Knuth, M.W., Koesema, E., Morse, A.T., Nigoghossian, E., Okach, L., Oommachen, S., Paulsen, J., Quijano, K., Reyes, R., Rife, C.L., van den Bedem, H., Weekes, D., White, A., Wolf, G., Xu, Q., Hodgson, K.O., Wooley, J., Deacon, A.M., Godzik, A., Lesley, S.A., Wilson, I.A.
Proteins