1 keywords

CATH Domain 1zczA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.140 Cytidine Deaminase; domain 2
Homologous Superfamily 3.40.140.20 AICAR transformylase, duplication domain

Domain Context

CATH Clusters

Superfamily 3.40.140.20
Functional Family

Enzyme Information

3.5.4.10
IMP cyclohydrolase.
based on mapping to UniProt Q9X0X6
IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
2.1.2.3
Phosphoribosylaminoimidazolecarboxamide formyltransferase.
based on mapping to UniProt Q9X0X6
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.

UniProtKB Entries (1)

Q9X0X6
PUR9_THEMA
Thermotoga maritima MSB8
Bifunctional purine biosynthesis protein PurH

PDB Structure

PDB 1ZCZ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 A resolution.
Axelrod, H.L., McMullan, D., Krishna, S.S., Miller, M.D., Elsliger, M.A., Abdubek, P., Ambing, E., Astakhova, T., Carlton, D., Chiu, H.J., Clayton, T., Duan, L., Feuerhelm, J., Grzechnik, S.K., Hale, J., Han, G.W., Haugen, J., Jaroszewski, L., Jin, K.K., Klock, H.E., Knuth, M.W., Koesema, E., Morse, A.T., Nigoghossian, E., Okach, L., Oommachen, S., Paulsen, J., Quijano, K., Reyes, R., Rife, C.L., van den Bedem, H., Weekes, D., White, A., Wolf, G., Xu, Q., Hodgson, K.O., Wooley, J., Deacon, A.M., Godzik, A., Lesley, S.A., Wilson, I.A.
Proteins