CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.565 | Heat Shock Protein 90 | |
3.30.565.10 | Histidine kinase-like ATPase, C-terminal domain |
Domain Context
CATH Clusters
Superfamily | Histidine kinase-like ATPase, C-terminal domain |
Functional Family | Type 2 DNA topoisomerase 6 subunit B |
Enzyme Information
5.6.2.3 |
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt O05207
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.
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UniProtKB Entries (1)
O05207 |
TOP6B_SACSH
Saccharolobus shibatae
Type 2 DNA topoisomerase 6 subunit B
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PDB Structure
PDB | 1Z5A |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Structural dissection of ATP turnover in the prototypical GHL ATPase TopoVI.
Structure
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