CATH Classification
Domain Context
CATH Clusters
| Superfamily | N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 |
| Functional Family | Ketol-acid reductoisomerase (NADP(+)) |
Enzyme Information
| 1.1.1.86 |
Ketol-acid reductoisomerase (NADP(+)).
based on mapping to UniProt P05793
(1) (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-hydroxy-2- methyl-3-oxobutanoate + NADPH. (2) (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2- ethyl-3-oxobutanoate + NADPH.
-!- The enzyme, found in many bacteria and archaea, is specific for NADPH (cf. EC 1.1.1.382 and EC 1.1.1.383). -!- Formerly EC 1.1.1.89.
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UniProtKB Entries (1)
| P05793 |
ILVC_ECOLI
Escherichia coli K-12
Ketol-acid reductoisomerase (NADP(+))
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PDB Structure
| PDB | 1YRL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The crystal structure of a bacterial class II ketol-acid reductoisomerase: domain conservation and evolution
Protein Sci.
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