CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.340 | Endonuclease III; domain 1 | |
1.10.340.30 | Hypothetical protein; domain 2 |
Domain Context
CATH Clusters
Superfamily | Hypothetical protein; domain 2 |
Functional Family | N-glycosylase/DNA lyase isoform X2 |
Enzyme Information
3.2.2.- |
Hydrolyzing N-glycosyl compounds.
based on mapping to UniProt O15527
|
4.2.99.18 |
DNA-(apurinic or apyrimidinic site) lyase.
based on mapping to UniProt O15527
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
-!- 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. -!- This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.
|
UniProtKB Entries (1)
O15527 |
OGG1_HUMAN
Homo sapiens
N-glycosylase/DNA lyase
|
PDB Structure
PDB | 1YQR |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA.
Nature
|