CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.90 | Alpha-Beta Complex | |
3.90.700 | Flavocytochrome C3; Chain A, domain 1 | |
3.90.700.10 | Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain |
Domain Context
CATH Clusters
Superfamily | Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain |
Functional Family | Mitochondrial succinate dehydrogenase flavoprotein subunit |
Enzyme Information
1.3.5.1 |
Succinate dehydrogenase (quinone).
based on mapping to UniProt Q9YHT1
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.
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UniProtKB Entries (1)
Q9YHT1 |
SDHA_CHICK
Gallus gallus
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
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PDB Structure
PDB | 1YQ3 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
3-Nitropropionic Acid Is a Suicide Inhibitor of Mitochondrial Respiration That, upon Oxidation by Complex II, Forms a Covalent Adduct with a Catalytic Base Arginine in the Active Site of the Enzyme
J.Biol.Chem.
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