CATH Domain 1yq3A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.700	Flavocytochrome C3; Chain A, domain 1
	3.90.700.10	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain

Domain Context

CATH Clusters

Superfamily	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
Functional Family	Mitochondrial succinate dehydrogenase flavoprotein subunit

Enzyme Information

1.3.5.1

Succinate dehydrogenase (quinone).

based on mapping to UniProt Q9YHT1

Succinate + a quinone = fumarate + a quinol.

-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.

UniProtKB Entries (1)

Q9YHT1

SDHA_CHICK

Gallus gallus

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

PDB Structure

PDB	1YQ3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	3-Nitropropionic Acid Is a Suicide Inhibitor of Mitochondrial Respiration That, upon Oxidation by Complex II, Forms a Covalent Adduct with a Catalytic Base Arginine in the Active Site of the Enzyme Huang, L., Sun, G., Cobessi, D., Wang, A.C., Shen, J.T., Tung, E.Y., Anderson, V.E., Berry, E.A. J.Biol.Chem.