CATH Domain 1youA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.390	Collagenase (Catalytic Domain)
	3.40.390.10	Collagenase (Catalytic Domain)

Domain Context

CATH Clusters

Superfamily	Collagenase (Catalytic Domain)
Functional Family	Collagenase 3

Enzyme Information

3.4.24.-

Metalloendopeptidases.

based on mapping to UniProt P45452

UniProtKB Entries (1)

MMP13_HUMAN

Homo sapiens

Collagenase 3

PDB Structure

PDB	1YOU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14. Blagg, J.A., Noe, M.C., Wolf-Gouveia, L.A., Reiter, L.A., Laird, E.R., Chang, S.P., Danley, D.E., Downs, J.T., Elliott, N.C., Eskra, J.D., Griffiths, R.J., Hardink, J.R., Haugeto, A.I., Jones, C.S., Liras, J.L., Lopresti-Morrow, L.L., Mitchell, P.G., Pandit, J., Robinson, R.P., Subramanyam, C., Vaughn-Bowser, M.L., Yocum, S.A. Bioorg.Med.Chem.Lett.