CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.75 | 5-stranded Propeller |
|
3.75.10 | L-arginine/glycine Amidinotransferase; Chain A |
|
3.75.10.20 | Succinylarginine dihydrolase |
Domain Context
CATH Clusters
| Superfamily | Succinylarginine dihydrolase |
| Functional Family | N-succinylarginine dihydrolase |
Enzyme Information
| 3.5.3.23 |
N-succinylarginine dihydrolase.
based on mapping to UniProt P76216
N(2)-succinyl-L-arginine + 2 H(2)O = N(2)-succinyl-L-ornithine + 2 NH(3) + CO(2).
-!- Arginine, N(2)-acetylarginine and N(2)-glutamylarginine do not act as substrates. -!- The second enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine. -!- This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. -!- The five enzymes involved in this pathway are EC 2.3.1.109, EC 3.5.3.23, EC 2.6.1.11, EC 1.2.1.71 and EC 3.5.1.96.
|
UniProtKB Entries (1)
| P76216 |
ASTB_ECOLI
Escherichia coli K-12
N-succinylarginine dihydrolase
|
PDB Structure
| PDB | 1YNI |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of N-succinylarginine dihydrolase AstB, bound to substrate and product, an enzyme from the arginine catabolic pathway of Escherichia coli.
J.Biol.Chem.
|