CATH Classification

Domain Context

CATH Clusters

Superfamily Succinylarginine dihydrolase
Functional Family N-succinylarginine dihydrolase

Enzyme Information

3.5.3.23
N-succinylarginine dihydrolase.
based on mapping to UniProt P76216
N(2)-succinyl-L-arginine + 2 H(2)O = N(2)-succinyl-L-ornithine + 2 NH(3) + CO(2).
-!- Arginine, N(2)-acetylarginine and N(2)-glutamylarginine do not act as substrates. -!- The second enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine. -!- This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. -!- The five enzymes involved in this pathway are EC 2.3.1.109, EC 3.5.3.23, EC 2.6.1.11, EC 1.2.1.71 and EC 3.5.1.96.

UniProtKB Entries (1)

P76216
ASTB_ECOLI
Escherichia coli K-12
N-succinylarginine dihydrolase

PDB Structure

PDB 1YNH
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of N-succinylarginine dihydrolase AstB, bound to substrate and product, an enzyme from the arginine catabolic pathway of Escherichia coli.
Tocilj, A., Schrag, J.D., Li, Y., Schneider, B.L., Reitzer, L., Matte, A., Cygler, M.
J.Biol.Chem.