CATH Domain 1yk8A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family

Enzyme Information

3.4.22.38

Cathepsin K.

based on mapping to UniProt P43235

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

-!- Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P43235

CATK_HUMAN

Homo sapiens

Cathepsin K

PDB Structure

PDB	1YK8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Acyclic cyanamide-based inhibitors of cathepsin K. Barrett, D.G., Deaton, D.N., Hassell, A.M., McFadyen, R.B., Miller, A.B., Miller, L.R., Payne, J.A., Shewchuk, L.M., Willard, D.H., Wright, L.L. Bioorg.Med.Chem.Lett.