CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.200 | Tumour Suppressor Smad4 |
|
2.60.200.20 |
Domain Context
CATH Clusters
| Superfamily | 2.60.200.20 |
| Functional Family | bifunctional polynucleotide phosphatase/kinase |
Enzyme Information
| 2.7.1.78 |
Polynucleotide 5'-hydroxyl-kinase.
based on mapping to UniProt Q9JLV6
ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA.
-!- Also acts on 5'-dephospho-RNA 3'-mononucleotides.
|
| 3.1.3.32 |
Polynucleotide 3'-phosphatase.
based on mapping to UniProt Q9JLV6
A 3'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate.
-!- Also hydrolyzes nucleoside 2'-, 3'- and 5'-monophosphates, but only 2'- and 3'-phosphopolynucleotides.
|
UniProtKB Entries (1)
| Q9JLV6 |
PNKP_MOUSE
Mus musculus
Bifunctional polynucleotide phosphatase/kinase
|
PDB Structure
| PDB | 1YJ5 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase.
Mol.Cell
|