CATH Domain 1yisA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.200	Fumarase C; Chain A, domain 2
	1.20.200.10	Fumarase/aspartase (Central domain)

Domain Context

CATH Clusters

Superfamily	Fumarase/aspartase (Central domain)
Functional Family

Enzyme Information

4.3.2.2

Adenylosuccinate lyase.

based on mapping to UniProt Q21774

(1) N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP. (2) (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.

-!- Also acts on 1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5- aminoimidazole.

UniProtKB Entries (1)

Q21774

PUR8_CAEEL

Caenorhabditis elegans

Adenylosuccinate lyase

PDB Structure

PDB	1YIS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural genomics of Caenorhabditis elegans: adenylosuccinate lyase Symersky, J., Schormann, N., Lu, S., Zhang, Y., Karpova, E., Qiu, S., Huang, W., Cao, Z., Zhou, J., Luo, M., Arabshahi, A., McKinstry, A., Luan, C.-H., Luo, D., Johnson, D., An, J., Tsao, J., Delucas, L., Shang, Q., Gray, R., Li, S., Bray, T., Chen, Y.-J. To be Published