CATH Domain 1yf8A02

CATH Classification

Level	CATH Code	Description
	4	Few Secondary Structures
	4.10	Irregular
	4.10.470	Ricin (A Subunit), domain 2
	4.10.470.10	Ricin (A Subunit), domain 2

Domain Context

CATH Clusters

Superfamily	Ricin (A Subunit), domain 2
Functional Family

Enzyme Information

3.2.2.22

rRNA N-glycosylase.

based on mapping to UniProt Q6ITZ3

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

Q6ITZ3

ML4_VISAL

Viscum album

Beta-galactoside-specific lectin 4

PDB Structure

PDB	1YF8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of himalayan mistletoe ribosome-inactivating protein reveals the presence of a natural inhibitor and a new functionally active sugar-binding site. Mishra, V., Bilgrami, S., Sharma, R.S., Kaur, P., Yadav, S., Krauspenhaar, R., Betzel, C., Voelter, W., Babu, C.R., Singh, T.P. J.Biol.Chem.