CATH Classification

Domain Context

CATH Clusters

Superfamily Adenine-specific Methyltransferase, Domain 2
Functional Family

Enzyme Information

2.1.1.72
Site-specific DNA-methyltransferase (adenine-specific).
based on mapping to UniProt P04392
S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N-6-methyladenine in DNA.
-!- This is a large group of enzymes, most of which form so-called 'restriction-modification systems', with nucleases that possess similar site specificity (the nucleases are listed as either EC 3.1.21.3, EC 3.1.21.4 and EC 3.1.21.5). -!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/

UniProtKB Entries (1)

P04392
DMA_BPT4
Escherichia virus T4
DNA adenine methylase

PDB Structure

PDB 1YF3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Transition from Nonspecific to Specific DNA Interactions along the Substrate-Recognition Pathway of Dam Methyltransferase.
Horton, J.R., Liebert, K., Hattman, S., Jeltsch, A., Cheng, X.
Cell(Cambridge,Mass.)
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