CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family quinone oxidoreductase

Enzyme Information

1.6.5.5
NADPH:quinone reductase.
based on mapping to UniProt Q08257
NADPH + 2 quinone = NADP(+) + 2 semiquinone.
-!- Specific for NADPH. -!- Catalyzes the one-electron reduction of certain quinones, with the orthoquinones 1,2-naphthoquinone and 9,10-phenanthrenequinone being the best substrates. -!- Dicoumarol (cf. EC 1.6.5.2) and nitrofurantoin are competitive inhibitors with respect to the quinone substrate. -!- The semiquinone free-radical product may be non-enzymically reduced to the hydroquinone or oxidized back to quinone in the presence of O(2). -!- Abundant in the lens of the eye of some mammalian species.

UniProtKB Entries (1)

Q08257
QOR_HUMAN
Homo sapiens
Quinone oxidoreductase

PDB Structure

PDB 1YB5
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of human Zeta-Crystallin at 1.85A
Debreczeni, J., Berridge, G., Kavanagh, K., Colbrook, S., Bray, J., Williams, L., Oppermann, U., Sundstrom, M., Arrowsmith, C., Edwards, A., Gileadi, O., von Delft, F.
To be Published