CATH Domain 1yaxA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.450	Beta-Lactamase
	3.30.450.140	PhoQ sensor domain

Domain Context

CATH Clusters

Superfamily	3.30.450.140
Functional Family	Virulence sensor histidine kinase PhoQ

Enzyme Information

2.7.13.3	Histidine kinase. based on mapping to UniProt P0DM80 ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. -!- This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine). -!- A number of histones can act as acceptor.
3.1.3.-	Phosphoric monoester hydrolases. based on mapping to UniProt P0DM80

UniProtKB Entries (1)

PHOQ_SALTY

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Virulence sensor histidine kinase PhoQ

PDB Structure

PDB	1YAX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Metal bridges between the PhoQ sensor domain and the membrane regulate transmembrane signaling. Cho, U.S., Bader, M.W., Amaya, M.F., Daley, M.E., Klevit, R.E., Miller, S.I., Xu, W. J.Mol.Biol.