CATH Domain 1y2mA03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.274	Enzyme I; Chain A, domain 2
	1.10.274.20	Phenylalanine ammonia-lyase 1; domain 3

Domain Context

CATH Clusters

Superfamily	Phenylalanine ammonia-lyase 1; domain 3
Functional Family

Enzyme Information

4.3.1.25

Phenylalanine/tyrosine ammonia-lyase.

based on mapping to UniProt P11544

(1) L-phenylalanine = trans-cinnamate + ammonia. (2) L-tyrosine = trans-p-hydroxycinnamate + ammonia.

-!- Member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3, EC 4.3.1.23 and EC 4.3.1.24. -!- The enzyme from some monocots, including maize, and from the yeast Rhodosporidium toruloides, deaminate L-phenylalanine and L-tyrosine with similar catalytic efficiency. -!- Formerly EC 4.3.1.5.

UniProtKB Entries (1)

P11544

PALY_RHOTO

Rhodotorula toruloides

Phenylalanine/tyrosine ammonia-lyase

PDB Structure

PDB	1Y2M
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure-based chemical modification strategy for enzyme replacement treatment of phenylketonuria. Wang, L., Gamez, A., Sarkissian, C.N., Straub, M., Patch, M.G., Han, G.W., Striepeke, S., Fitzpatrick, P., Scriver, C.R., Stevens, R.C. Mol.Genet.Metab.