CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.1360.140
Functional Family DNA-directed RNA polymerase subunit

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P04050
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P20433
RPB4_YEAST
Saccharomyces cerevisiae S288C
DNA-directed RNA polymerase II subunit RPB4

PDB Structure

PDB 1Y1V
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS.
Kettenberger, H., Armache, K.J., Cramer, P.
Mol.Cell
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