CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.40
Functional Family Peptidylprolyl isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q9SCY2
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q9SCY2
FKB13_ARATH
Arabidopsis thaliana
Peptidyl-prolyl cis-trans isomerase FKBP13, chloroplastic

PDB Structure

PDB 1Y0O
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of reduced AtFKBP13
Gopalan, G., Swaminthan, K., Luan, S., Battaile, K.P.
to be published