CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family 4-hydroxy-tetrahydrodipicolinate synthase

Enzyme Information

4.3.3.7
4-hydroxy-tetrahydrodipicolinate synthase.
based on mapping to UniProt P9WP25
Pyruvate + L-aspartate-4-semialdehyde = (4S)-4-hydroxy-2,3,4,5- tetrahydro-(2S)-dipicolinate + H(2)O.
-!- Formerly EC 4.2.1.52.

UniProtKB Entries (1)

P9WP25
DAPA_MYCTU
Mycobacterium tuberculosis H37Rv
4-hydroxy-tetrahydrodipicolinate synthase

PDB Structure

PDB 1XXX
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis.
Kefala, G., Evans, G.L., Griffin, M.D., Devenish, S.R., Pearce, F.G., Perugini, M.A., Gerrard, J.A., Weiss, M.S., Dobson, R.C.
Biochem.J.
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