CATH Domain 1xwnA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.100	Cyclophilin
	2.40.100.10	Cyclophilin-like

Domain Context

CATH Clusters

Superfamily	Cyclophilin-like
Functional Family	Peptidyl-prolyl cis-trans isomerase

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt Q9Y3C6

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q9Y3C6

PPIL1_HUMAN

Homo sapiens

Peptidyl-prolyl cis-trans isomerase-like 1

PDB Structure

PDB	1XWN
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism	Escherichia
Primary Citation	Solution structure of human peptidyl prolyl isomerase like protein 1 and insights into its interaction with SKIP Xu, C., Zhang, J., Huang, X., Sun, J., Xu, Y., Tang, Y., Wu, J., Shi, Y., Huang, Q., Zhang, Q. J.Biol.Chem.