CATH Domain 1xsaA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.79	Nucleoside Triphosphate Pyrophosphohydrolase
	3.90.79.10	Nucleoside Triphosphate Pyrophosphohydrolase

Domain Context

CATH Clusters

Superfamily	Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family	Nudix hydrolase 2

Enzyme Information

3.6.1.17

Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical).

based on mapping to UniProt P50583

P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H(2)O = GTP + GMP.

-!- Also acts on bis(5'-xanthosyl)-tetraphosphate and, more slowly, on bis(5'-adenosyl)-tetraphosphate and bis(5'-uridyl)-tetraphosphate (cf. EC 3.6.1.41).

UniProtKB Entries (1)

P50583

AP4A_HUMAN

Homo sapiens

Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

PDB Structure

PDB	1XSA
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism	Escherichia
Primary Citation	Structure and Substrate-binding Mechanism of Human Ap4A Hydrolase Swarbrick, J.D., Buyya, S., Gunawardana, D., Gayler, K.R., McLennan, A.G., Gooley, P.R. J.Biol.Chem.