CATH Classification

Domain Context

CATH Clusters

Superfamily Hypothetical protein; domain 2
Functional Family

Enzyme Information

3.2.2.-
Hydrolyzing N-glycosyl compounds.
based on mapping to UniProt Q8ZVK6
4.2.99.18
DNA-(apurinic or apyrimidinic site) lyase.
based on mapping to UniProt Q8ZVK6
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
-!- 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. -!- This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.

UniProtKB Entries (1)

Q8ZVK6
AGOG_PYRAE
Pyrobaculum aerophilum str. IM2
N-glycosylase/DNA lyase

PDB Structure

PDB 1XQO
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A DNA glycosylase from Pyrobaculum aerophilum with an 8-oxoguanine binding mode and a noncanonical helix-hairpin-helix structure
Lingaraju, G.M., Sartori, A.A., Kostrewa, D., Prota, A.E., Jiricny, J., Winkler, F.K.
Structure
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