CATH Domain 1xg7A01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1670	Endonuclease Iii, domain 2
	1.10.1670.10	Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)

Domain Context

CATH Clusters

Superfamily	Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)
Functional Family

Enzyme Information

3.2.2.-

Hydrolyzing N-glycosyl compounds.

based on mapping to UniProt Q8U2D5

4.2.99.18

DNA-(apurinic or apyrimidinic site) lyase.

based on mapping to UniProt Q8U2D5

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

-!- 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. -!- This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.

UniProtKB Entries (1)

Q8U2D5

AGOG_PYRFU

Pyrococcus furiosus DSM 3638

N-glycosylase/DNA lyase

PDB Structure

PDB	1XG7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Conserved hypothetical protein Pfu-877259-001 from Pyrococcus furiosus Chang, J., Zhao, M., Horanyi, P., Xu, H., Yang, H., Liu, Z.-J., Chen, L., Zhou, W., Habel, J., Tempel, W., Lee, D., Lin, D., Chang, S.-H., Eneh, J.C., Hopkins, R.C., Jenney Jr., F.E., Lee, H.-S., Li, T., Poole II, F.L., Shah, C., Sugar, F.J., CHEN, C.-Y., Arendall III, W.B., Richardson, J.S., Richardson, D.C., Rose, J.P., ADAMS, M.W.W., Wang, B.-C., Southeast Collaboratory for Structural Genomics To be published