CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Fructose-bisphosphate aldolase

Enzyme Information

4.1.2.13
Fructose-bisphosphate aldolase.
based on mapping to UniProt P05062
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
-!- Also acts on (3S,4R)-ketose 1-phosphates. -!- The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc. -!- Formerly EC 4.1.2.7.

UniProtKB Entries (1)

P05062
ALDOB_HUMAN
Homo sapiens
Fructose-bisphosphate aldolase B

PDB Structure

PDB 1XDL
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the thermolabile mutant aldolase B, A149P: molecular basis of hereditary fructose intolerance.
Malay, A.D., Allen, K.N., Tolan, D.R.
J.Mol.Biol.
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