CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.160 | Double Stranded RNA Binding Domain | |
3.30.160.20 |
Domain Context
CATH Clusters
Superfamily | 3.30.160.20 |
Functional Family | Eukaryotic translation initiation factor 2-alpha kinase 2 |
Enzyme Information
2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q03963
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
|
2.7.10.2 |
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q03963
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.
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UniProtKB Entries (1)
Q03963 |
E2AK2_MOUSE
Mus musculus
Interferon-induced, double-stranded RNA-activated protein kinase
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PDB Structure
PDB | 1X49 |
External Links | |
Method | SOLUTION NMR |
Organism | |
Primary Citation |
Solution structure of the first DSRM domain in Interferon-induced, double-stranded RNA-activated protein kinase
To be Published
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