CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.718 | Isopropylmalate Dehydrogenase |
|
3.40.718.10 | Isopropylmalate Dehydrogenase |
Domain Context
CATH Clusters
| Superfamily | Isopropylmalate Dehydrogenase |
| Functional Family | Homoisocitrate dehydrogenase |
Enzyme Information
| 1.1.1.87 |
Homoisocitrate dehydrogenase.
based on mapping to UniProt Q72IW9
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD(+) = 2-oxoadipate + CO(2) + NADH.
-!- Forms part of the lysine biosynthesis pathway in fungi. -!- Formerly EC 1.1.1.155.
|
UniProtKB Entries (1)
| Q72IW9 |
HICDH_THET2
Thermus thermophilus HB27
Homoisocitrate dehydrogenase
|
PDB Structure
| PDB | 1X0L |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal Structure of Tetrameric Homoisocitrate Dehydrogenase from an Extreme Thermophile, Thermus thermophilus: Involvement of Hydrophobic Dimer-Dimer Interaction in Extremely High Thermotolerance
J.Bacteriol.
|
