1 keywords

CATH Domain 1wziA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.110 L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
Homologous Superfamily 3.90.110.10 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

Domain Context

CATH Clusters

Superfamily Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family Malate dehydrogenase

Enzyme Information

1.1.1.37
Malate dehydrogenase.
based on mapping to UniProt P10584
(S)-malate + NAD(+) = oxaloacetate + NADH.
-!- Also oxidizes some other 2-hydroxydicarboxylic acids.

UniProtKB Entries (1)

P10584
MDH_THETH
Thermus thermophilus
Malate dehydrogenase

PDB Structure

PDB 1WZI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis for alteration of cofactor specificity of malate dehydrogenase from Thermus flavus
Tomita, T., Fushinobu, S., Kuzuyama, T., Nishiyama, M.
to be published