CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family Tyrosine-protein kinase receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P04629
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P04629
NTRK1_HUMAN
Homo sapiens
High affinity nerve growth factor receptor

PDB Structure

PDB 1WWW
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor.
Wiesmann, C., Ultsch, M.H., Bass, S.H., de Vos, A.M.
Nature