CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
4 | Few Secondary Structures |
|
4.10 | Irregular |
|
4.10.1250 | Aminomethyltransferase fragment |
|
4.10.1250.10 | Aminomethyltransferase fragment |
Domain Context
CATH Clusters
| Superfamily | Aminomethyltransferase fragment |
| Functional Family | Aminomethyltransferase |
Enzyme Information
| 2.1.2.10 |
Aminomethyltransferase.
based on mapping to UniProt P48728
[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH(3).
-!- A component, with EC 1.4.4.2 and EC 1.8.1.4, of the glycine cleavage system, formerly known as glycine synthase. -!- The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.
|
UniProtKB Entries (1)
| P48728 |
GCST_HUMAN
Homo sapiens
Aminomethyltransferase, mitochondrial
|
PDB Structure
| PDB | 1WSV |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal Structure of Human T-protein of Glycine Cleavage System at 2.0A Resolution and its Implication for Understanding Non-ketotic Hyperglycinemia
J.Mol.Biol.
|
