CATH Classification

Domain Context

CATH Clusters

Superfamily Heme oxygenase-like
Functional Family

Enzyme Information

1.14.14.18
Heme oxygenase (biliverdin-producing).
based on mapping to UniProt P71119
Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = biliverdin + Fe(2+) + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H(2)O.
-!- This mammalian enzyme participates in the degradation of heme. -!- The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules. -!- The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO. -!- The enzyme requires NAD(P)H and EC 1.6.2.4. -!- Cf. EC 1.14.15.20. -!- Formerly EC 1.14.99.3.

UniProtKB Entries (1)

P71119
HMUO_CORDI
Corynebacterium diphtheriae NCTC 13129
Heme oxygenase

PDB Structure

PDB 1WNV
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Roles of Distal Asp in Heme Oxygenase from Corynebacterium diphtheriae, HmuO: A WATER-DRIVEN OXYGEN ACTIVATION MECHANISM
Matsui, T., Furukawa, M., Unno, M., Tomita, T., Ikeda-Saito, M.
J.Biol.Chem.