CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.150 | DNA polymerase; domain 1 | |
1.10.150.170 | Putative methyltransferase TM0872, insert domain |
Domain Context
CATH Clusters
Superfamily | Putative methyltransferase TM0872, insert domain |
Functional Family |
Enzyme Information
2.1.1.199 |
16S rRNA (cytosine(1402)-N(4))-methyltransferase.
based on mapping to UniProt Q5SJD8
S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L- homocysteine + N(4)-methylcytosine(1402) in 16S rRNA.
-!- RsmH catalyzes the N(4)-methylation of cytosine(1402) and RsmI (EC 2.1.1.198) catalyzes the 2'-O-methylation of cytosine(1402) in 16S rRNA. -!- Both methylations are necessary for efficient translation initiation at the UUG and GUG codons.
|
UniProtKB Entries (1)
Q5SJD8 |
RSMH_THET8
Thermus thermophilus HB8
Ribosomal RNA small subunit methyltransferase H
|
PDB Structure
PDB | 1WG8 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Crystal structure of a predicted S-adenosylmethionine-dependent methyltransferase TT1512 from Thermus thermophilus HB8 at 2.0 Ang. resolution.
To be Published
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