CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase |
Enzyme Information
| 4.1.2.55 |
2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase.
based on mapping to UniProt O54288
(1) 2-dehydro-3-deoxy-6-phospho-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate. (2) 2-dehydro-3-deoxy-6-phospho-D-galactonate = pyruvate + D-glyceraldehyde 3-phosphate.
-!- In the archaeon Sulfolobus solfataricus the enzyme is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway. -!- It utilizes 2-dehydro-3-deoxy-6-phosphate-D-gluconate and 2-dehydro- 3-deoxy-6-phosphate-D-galactonate with similar catalytic efficiency. -!- In vitro the enzyme can also catalyze the cleavage of the non- phosphorylated forms 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3- deoxy-D-galactonate with much lower catalytic efficiency. -!- Cf. EC 4.1.2.21 and EC 4.1.2.14.
|
UniProtKB Entries (1)
| O54288 |
KDGA_SACSO
Saccharolobus solfataricus
2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
|
PDB Structure
| PDB | 1W3I |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus.
J. Biol. Chem.
|
