CATH Domain 1vr3A00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.10	Jelly Rolls

Domain Context

CATH Clusters

Superfamily	Jelly Rolls
Functional Family	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

Enzyme Information

1.13.11.54

Acireductone dioxygenase (Fe(2+)-requiring).

based on mapping to UniProt Q99JT9

1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-(methylthio)-2- oxobutanoate + formate.

-!- If Ni(2+) is bound instead of Fe(2+), the reaction catalyzed by EC 1.13.11.53 occurs instead. -!- The enzyme from Klebsiella oxytoca (formerly Klebsiella pneumoniae) ATCC 8724 is involved in the methionine salvage pathway.

UniProtKB Entries (1)

Q99JT9

MTND_MOUSE

Mus musculus

1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

PDB Structure

PDB	1VR3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 angstrom resolution. Xu, Q., Schwarzenbacher, R., Krishna, S.S., McMullan, D., Agarwalla, S., Quijano, K., Abdubek, P., Ambing, E., Axelrod, H., Biorac, T., Canaves, J.M., Chiu, H.J., Elsliger, M.A., Grittini, C., Grzechnik, S.K., DiDonato, M., Hale, J., Hampton, E., Han, G.W., Haugen, J., Hornsby, M., Jaroszewski, L., Klock, H.E., Knuth, M.W., Koesema, E., Kreusch, A., Kuhn, P., Miller, M.D., Moy, K., Nigoghossian, E., Paulsen, J., Reyes, R., Rife, C., Spraggon, G., Stevens, R.C., van den Bedem, H., Velasquez, J., White, A., Wolf, G., Hodgson, K.O., Wooley, J., Deacon, A.M., Godzik, A., Lesley, S.A., Wilson, I.A. Proteins