CATH Domain 1vkbA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.490	Hypothetical upf0131 protein ytfp
	3.10.490.10	Gamma-glutamyl cyclotransferase-like

Domain Context

CATH Clusters

Superfamily	Gamma-glutamyl cyclotransferase-like
Functional Family	Gamma-glutamylaminecyclotransferase A

Enzyme Information

4.3.2.8

Gamma-glutamylamine cyclotransferase.

based on mapping to UniProt Q923B0

Epsilon-(gamma-L-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline.

-!- The enzyme, found in vertebrates, has no activity toward alpha- (gamma-L-glutamyl)-L-amino acids (cf. EC 4.3.2.9). -!- The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the gamma-L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.

UniProtKB Entries (1)

Q923B0

GGACT_MOUSE

Mus musculus

Gamma-glutamylaminecyclotransferase

PDB Structure

PDB	1VKB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of a conserved hypothetical protein (gi: 13879369) from Mouse at 1.90 A resolution reveals a new fold. Klock, H.E., Schwarzenbacher, R., Xu, Q., McMullan, D., Abdubek, P., Ambing, E., Axelrod, H., Biorac, T., Canaves, J.M., Chiu, H.J., Deacon, A.M., DiDonato, M., Elsliger, M.A., Godzik, A., Grittini, C., Grzechnik, S.K., Hale, J., Hampton, E., Han, G.W., Haugen, J., Hornsby, M., Jaroszewski, L., Koesema, E., Kreusch, A., Kuhn, P., Miller, M.D., Moy, K., Nigoghossian, E., Paulsen, J., Quijano, K., Reyes, R., Rife, C., Sims, E., Spraggon, G., Stevens, R.C., van den Bedem, H., Velasquez, J., Vincent, J., White, A., Wolf, G., Hodgson, K.O., Wooley, J., Lesley, S.A., Wilson, I.A. Proteins