CATH Classification

Domain Context

CATH Clusters

Superfamily DNA topoisomerase I domain
Functional Family

Enzyme Information

5.6.2.2
DNA topoisomerase.
based on mapping to UniProt P68698
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.3. -!- Formerly EC 5.99.1.2.

UniProtKB Entries (1)

P68698
TOP1_VACCW
Vaccinia virus WR
DNA topoisomerase 1B

PDB Structure

PDB 1VCC
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the amino-terminal fragment of vaccinia virus DNA topoisomerase I at 1.6 A resolution.
Sharma, A., Hanai, R., Mondragon, A.
Structure