CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.450 | Beta-Lactamase | |
3.30.450.20 | PAS domain |
Domain Context
CATH Clusters
Superfamily | PAS domain |
Functional Family | Oxygen sensor protein DosP |
Enzyme Information
3.1.4.52 |
Cyclic-guanylate-specific phosphodiesterase.
based on mapping to UniProt P76129
Cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine.
-!- Inhibited by Ca(2+) and Zn(2+). -!- Linearizes cyclic di-3',5'-guanylate, the product of EC 2.7.7.65 and an allosteric activator of EC 2.4.1.12 rendering it inactive. -!- It is the balance between these two enzymes that determines the cellular level of cyclic di-3',5'-guanylate.
|
UniProtKB Entries (1)
P76129 |
DOSP_ECOLI
Escherichia coli K-12
Oxygen sensor protein DosP
|
PDB Structure
PDB | 1V9Z |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
A redox-controlled molecular switch revealed by the crystal structure of a bacterial heme PAS sensor.
J.Biol.Chem.
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