CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.90 | Alpha-Beta Complex | |
3.90.780 | 5'-nucleotidase; domain 2 | |
3.90.780.10 | 5'-Nucleotidase, C-terminal domain |
Domain Context
CATH Clusters
Superfamily | 5'-Nucleotidase, C-terminal domain |
Functional Family | Protein UshA |
Enzyme Information
3.6.1.45 |
UDP-sugar diphosphatase.
based on mapping to UniProt P07024
UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate.
-!- UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities. -!- Thus, this enzyme has a specificity distinct from that of EC 3.6.1.21. -!- Some but not all enzymes of this class also appear to have EC 3.1.3.5 activity.
|
3.1.3.5 |
5'-nucleotidase.
based on mapping to UniProt P07024
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
-!- Wide specificity for 5'-nucleotides.
|
UniProtKB Entries (1)
P07024 |
USHA_ECOLI
Escherichia coli K-12
Protein UshA
|
PDB Structure
PDB | 1USH |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
X-ray structure of the Escherichia coli periplasmic 5'-nucleotidase containing a dimetal catalytic site.
Nat.Struct.Biol.
|