CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1220 | TPP-binding domain |
Domain Context
CATH Clusters
| Superfamily | TPP-binding domain |
| Functional Family | N(2)-(2-carboxyethyl)arginine synthase |
Enzyme Information
| 2.5.1.66 |
N(2)-(2-carboxyethyl)arginine synthase.
based on mapping to UniProt Q9LCV9
D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L- arginine + phosphate.
-!- Requires thiamine diphosphate and catalyzes the first step in the clavulanic-acid biosynthesis pathway. -!- The 2-hydroxy-3-oxo group transferred from glyceraldehyde 3-phosphate is isomerized during transfer to form the 2-carboxyethyl group.
|
UniProtKB Entries (1)
| Q9LCV9 |
CEAS_STRCL
Streptomyces clavuligerus
N(2)-(2-carboxyethyl)arginine synthase
|
PDB Structure
| PDB | 1UPC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure and Mechanistic Implications of N2-(2-Carboxyethyl)Arginine Synthase, the First Enzyme in the Clavulanic Acid Biosynthesis Pathway
J.Biol.Chem.
|