CATH Domain 1upaC02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1220	TPP-binding domain

Domain Context

CATH Clusters

Superfamily	TPP-binding domain
Functional Family

Enzyme Information

2.5.1.66

N(2)-(2-carboxyethyl)arginine synthase.

based on mapping to UniProt Q9LCV9

D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L- arginine + phosphate.

-!- Requires thiamine diphosphate and catalyzes the first step in the clavulanic-acid biosynthesis pathway. -!- The 2-hydroxy-3-oxo group transferred from glyceraldehyde 3-phosphate is isomerized during transfer to form the 2-carboxyethyl group.

UniProtKB Entries (1)

Q9LCV9

CEAS_STRCL

Streptomyces clavuligerus

N(2)-(2-carboxyethyl)arginine synthase

PDB Structure

PDB	1UPA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure and Mechanistic Implications of N2-(2-Carboxyethyl)Arginine Synthase, the First Enzyme in the Clavulanic Acid Biosynthesis Pathway Caines, M.E.C., Elkins, J.M., Hewitson, K.S., Schofield, C.J. J.Biol.Chem.