CATH Domain 1umwA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1120	Arylsulfatase, C-terminal domain
	3.30.1120.30	POLO box domain

Domain Context

CATH Clusters

Superfamily	POLO box domain
Functional Family	Serine/threonine-protein kinase PLK

Enzyme Information

2.7.11.21

Polo kinase.

based on mapping to UniProt P53350

ATP + a protein = ADP + a phosphoprotein.

-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P53350

PLK1_HUMAN

Homo sapiens

Serine/threonine-protein kinase PLK1

PDB Structure

PDB	1UMW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Molecular Basis for Phosphodependent Substrate Targeting and Regulation of Plks by the Polo-Box Domain Elia, A., Rellos, P., Haire, L., Chao, J., Ivins, F., Hoepker, K., Mohammad, D., Cantley, L., Smerdon, S.J., Yaffe, M.B. Cell(Cambridge,Mass.)