CATH Domain 1uk1A01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.142	Poly(ADP-ribose) Polymerase; domain 1
	1.20.142.10	Poly(ADP-ribose) polymerase, regulatory domain

Domain Context

CATH Clusters

Superfamily	Poly(ADP-ribose) polymerase, regulatory domain
Functional Family	Poly [ADP-ribose] polymerase

Enzyme Information

2.4.2.-

Pentosyltransferases.

based on mapping to UniProt P09874

2.4.2.30

NAD(+) ADP-ribosyltransferase.

based on mapping to UniProt P09874

NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.

-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

UniProtKB Entries (1)

P09874

PARP1_HUMAN

Homo sapiens

Poly [ADP-ribose] polymerase 1

PDB Structure

PDB	1UK1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase Hattori, K., Kido, Y., Yamamoto, H., Ishida, J., Kamijo, K., Murano, K., Ohkubo, M., Kinoshita, T., Iwashita, A., Mihara, K., Yamazaki, S., Matsuoka, N., Teramura, Y., Miyake, H. J.Med.Chem.