CATH Domain 1uc8A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1490	Dna Ligase; domain 1
	3.30.1490.20	ATP-grasp fold, A domain

Domain Context

CATH Clusters

Superfamily	ATP-grasp fold, A domain
Functional Family

Enzyme Information

6.3.2.43

[Amino group carrier protein]--L-2-aminoadipate ligase.

based on mapping to UniProt Q5SH23

ATP + [amino group carrier protein]-C-terminal-L-glutamate + L-2- aminoadipate = ADP + phosphate + [amino group carrier protein]-C- terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate.

-!- The enzymes from the thermophilic bacterium Thermus thermophilus and the thermophilic archaea Sulfolobus acidocaldarius and Sulfolobus tokodaii protect the amino group of L-2-aminoadipate by conjugation to the carrier protein LysW. -!- This reaction is part of the lysine biosynthesis pathway in these organisms. -!- Formerly EC 6.3.2.n4.

UniProtKB Entries (1)

Q5SH23

LYSX_THET8

Thermus thermophilus HB8

Alpha-aminoadipate--LysW ligase LysX

PDB Structure

PDB	1UC8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal Structure of a Lysine Biosynthesis Enzyme, LysX, from Thermus thermophilus HB8 Sakai, H., Vassylyeva, M.N., Matsuura, T., Sekine, S., Gotoh, K., Nishiyama, M., Terada, T., Shirouzu, M., Kuramitsu, S., Vassylyev, D.G., Yokoyama, S. J.Mol.Biol.