CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family Glutathione reductase

Enzyme Information

1.8.1.12
Trypanothione-disulfide reductase.
based on mapping to UniProt P39040
Trypanothione + NADP(+) = trypanothione disulfide + NADPH.
-!- Trypanothione disulfide is the oxidized form of N(1),N(8)- bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata. -!- The activity is dependent on a redox-active cystine at the active center (cf. EC 1.8.1.7). -!- Formerly EC 1.6.4.8.

UniProtKB Entries (1)

P39040
TYTR_CRIFA
Crithidia fasciculata
Trypanothione reductase

PDB Structure

PDB 1TYT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of trypanothione reductase from Crithidia fasciculata at 2.6 A resolution; enzyme-NADP interactions at 2.8 A resolution.
Bailey, S., Fairlamb, A.H., Hunter, W.N.
Acta Crystallogr.,Sect.D