CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
4 | Few Secondary Structures |
|
4.10 | Irregular |
|
4.10.860 | DNA Excision Repair, Uvrb; Chain A |
|
4.10.860.120 | RNA polymerase II, clamp domain |
Domain Context
CATH Clusters
| Superfamily | RNA polymerase II, clamp domain |
| Functional Family | DNA-directed RNA polymerase subunit |
Enzyme Information
| 2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt P04050
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
|
UniProtKB Entries (1)
| P20434 |
RPAB1_YEAST
Saccharomyces cerevisiae S288C
DNA-directed RNA polymerases I, II, and III subunit RPABC1
|
PDB Structure
| PDB | 1TWH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center.
Cell(Cambridge,Mass.)
|
